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purified human platelet tsp1  (Millipore)

 
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    Structured Review

    Millipore purified human platelet tsp1
    Thrombospondin 1 <t>(TSP1)</t> induced LSEC defenestration. (A) SEM images of LSEC after treatment with different doses (0 ng/ml, 10 ng/ml and 100 ng/ml) of TSP1 for 12 h. Scale bars represent 1 μm. White asterisks (*) indicate fenestrae or clusters of fenestrae (sieve plates). (B) Porosity/μm 2 (black bars, represent fenestrae area) and Fenestrae number/μm 2 (white bars, represent the absolute number of fenestrae) observed in LSEC after treatment with different doses of TSP1 (* represents P < 0.05 with Student's t -test).
    Purified Human Platelet Tsp1, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/purified human platelet tsp1/product/Millipore
    Average 90 stars, based on 1 article reviews
    purified human platelet tsp1 - by Bioz Stars, 2026-03
    90/100 stars

    Images

    1) Product Images from "The CD47-binding peptide of thrombospondin-1 induces defenestration of liver sinusoidal endothelial cells"

    Article Title: The CD47-binding peptide of thrombospondin-1 induces defenestration of liver sinusoidal endothelial cells

    Journal: Liver International

    doi: 10.1111/liv.12231

    Thrombospondin 1 (TSP1) induced LSEC defenestration. (A) SEM images of LSEC after treatment with different doses (0 ng/ml, 10 ng/ml and 100 ng/ml) of TSP1 for 12 h. Scale bars represent 1 μm. White asterisks (*) indicate fenestrae or clusters of fenestrae (sieve plates). (B) Porosity/μm 2 (black bars, represent fenestrae area) and Fenestrae number/μm 2 (white bars, represent the absolute number of fenestrae) observed in LSEC after treatment with different doses of TSP1 (* represents P < 0.05 with Student's t -test).
    Figure Legend Snippet: Thrombospondin 1 (TSP1) induced LSEC defenestration. (A) SEM images of LSEC after treatment with different doses (0 ng/ml, 10 ng/ml and 100 ng/ml) of TSP1 for 12 h. Scale bars represent 1 μm. White asterisks (*) indicate fenestrae or clusters of fenestrae (sieve plates). (B) Porosity/μm 2 (black bars, represent fenestrae area) and Fenestrae number/μm 2 (white bars, represent the absolute number of fenestrae) observed in LSEC after treatment with different doses of TSP1 (* represents P < 0.05 with Student's t -test).

    Techniques Used:

    Thrombospondin 1 (TSP1)-induced defenestration was independent of TGF-β1 signalling. (A) SEM images of liver sinusoidal endothelial cells (LSEC)s pretreated with SB-431542 for 1 h before addition of TGF-β1 or TSP1 (a) Control; (b) SB-431542; (c) TSP1; (d) SB-431542+TSP1; (e) TGF-β1; (f) SB-431542+TGF-β1. All scale bars are 1 μm. (B) Porosity/μm 2 and (C) Fenestrae number/μm 2 after treatment with SB-431542, TSP1 and TGF-β1 (* represents P < 0.05 for one-way anova applied to the control, TSP1, and SB-431542+TSP1 treatments).
    Figure Legend Snippet: Thrombospondin 1 (TSP1)-induced defenestration was independent of TGF-β1 signalling. (A) SEM images of liver sinusoidal endothelial cells (LSEC)s pretreated with SB-431542 for 1 h before addition of TGF-β1 or TSP1 (a) Control; (b) SB-431542; (c) TSP1; (d) SB-431542+TSP1; (e) TGF-β1; (f) SB-431542+TGF-β1. All scale bars are 1 μm. (B) Porosity/μm 2 and (C) Fenestrae number/μm 2 after treatment with SB-431542, TSP1 and TGF-β1 (* represents P < 0.05 for one-way anova applied to the control, TSP1, and SB-431542+TSP1 treatments).

    Techniques Used: Control

    Defenestration was induced by a peptide from the Thrombospondin 1 (TSP)1 C-terminal domain. (A) Domains of TSP1 and the origins of the recombinant peptides from the C-terminal binding domain (CBD). Amino acid residues differing from the native TSP1 residues are underlined. (B) Porosity/μm 2 and (C) Fenestrae number/μm 2 of liver sinusoidal endothelial cells (LSEC) after treatment with CBD peptides. (D) Distribution of LSEC fenestrae diameter after peptide treatment. (* represents P < 0.05 for one-way anova applied to Control, p4N1 and p4G1 treatments).
    Figure Legend Snippet: Defenestration was induced by a peptide from the Thrombospondin 1 (TSP)1 C-terminal domain. (A) Domains of TSP1 and the origins of the recombinant peptides from the C-terminal binding domain (CBD). Amino acid residues differing from the native TSP1 residues are underlined. (B) Porosity/μm 2 and (C) Fenestrae number/μm 2 of liver sinusoidal endothelial cells (LSEC) after treatment with CBD peptides. (D) Distribution of LSEC fenestrae diameter after peptide treatment. (* represents P < 0.05 for one-way anova applied to Control, p4N1 and p4G1 treatments).

    Techniques Used: Recombinant, Binding Assay, Control



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    Thrombospondin 1 <t>(TSP1)</t> induced LSEC defenestration. (A) SEM images of LSEC after treatment with different doses (0 ng/ml, 10 ng/ml and 100 ng/ml) of TSP1 for 12 h. Scale bars represent 1 μm. White asterisks (*) indicate fenestrae or clusters of fenestrae (sieve plates). (B) Porosity/μm 2 (black bars, represent fenestrae area) and Fenestrae number/μm 2 (white bars, represent the absolute number of fenestrae) observed in LSEC after treatment with different doses of TSP1 (* represents P < 0.05 with Student's t -test).
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    Thrombospondin 1 <t>(TSP1)</t> induced LSEC defenestration. (A) SEM images of LSEC after treatment with different doses (0 ng/ml, 10 ng/ml and 100 ng/ml) of TSP1 for 12 h. Scale bars represent 1 μm. White asterisks (*) indicate fenestrae or clusters of fenestrae (sieve plates). (B) Porosity/μm 2 (black bars, represent fenestrae area) and Fenestrae number/μm 2 (white bars, represent the absolute number of fenestrae) observed in LSEC after treatment with different doses of TSP1 (* represents P < 0.05 with Student's t -test).
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    Thrombospondin 1 <t>(TSP1)</t> induced LSEC defenestration. (A) SEM images of LSEC after treatment with different doses (0 ng/ml, 10 ng/ml and 100 ng/ml) of TSP1 for 12 h. Scale bars represent 1 μm. White asterisks (*) indicate fenestrae or clusters of fenestrae (sieve plates). (B) Porosity/μm 2 (black bars, represent fenestrae area) and Fenestrae number/μm 2 (white bars, represent the absolute number of fenestrae) observed in LSEC after treatment with different doses of TSP1 (* represents P < 0.05 with Student's t -test).
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    Thrombospondin 1 <t>(TSP1)</t> induced LSEC defenestration. (A) SEM images of LSEC after treatment with different doses (0 ng/ml, 10 ng/ml and 100 ng/ml) of TSP1 for 12 h. Scale bars represent 1 μm. White asterisks (*) indicate fenestrae or clusters of fenestrae (sieve plates). (B) Porosity/μm 2 (black bars, represent fenestrae area) and Fenestrae number/μm 2 (white bars, represent the absolute number of fenestrae) observed in LSEC after treatment with different doses of TSP1 (* represents P < 0.05 with Student's t -test).
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    Image Search Results


    Thrombospondin 1 (TSP1) induced LSEC defenestration. (A) SEM images of LSEC after treatment with different doses (0 ng/ml, 10 ng/ml and 100 ng/ml) of TSP1 for 12 h. Scale bars represent 1 μm. White asterisks (*) indicate fenestrae or clusters of fenestrae (sieve plates). (B) Porosity/μm 2 (black bars, represent fenestrae area) and Fenestrae number/μm 2 (white bars, represent the absolute number of fenestrae) observed in LSEC after treatment with different doses of TSP1 (* represents P < 0.05 with Student's t -test).

    Journal: Liver International

    Article Title: The CD47-binding peptide of thrombospondin-1 induces defenestration of liver sinusoidal endothelial cells

    doi: 10.1111/liv.12231

    Figure Lengend Snippet: Thrombospondin 1 (TSP1) induced LSEC defenestration. (A) SEM images of LSEC after treatment with different doses (0 ng/ml, 10 ng/ml and 100 ng/ml) of TSP1 for 12 h. Scale bars represent 1 μm. White asterisks (*) indicate fenestrae or clusters of fenestrae (sieve plates). (B) Porosity/μm 2 (black bars, represent fenestrae area) and Fenestrae number/μm 2 (white bars, represent the absolute number of fenestrae) observed in LSEC after treatment with different doses of TSP1 (* represents P < 0.05 with Student's t -test).

    Article Snippet: To show the long-term, general effect of TSP1 on LSECs, cells in were treated for 12 h with different doses (0 ng/ml, 10 ng/ml and 100 ng/ml) of purified human platelet TSP1 (Millipore, Billerica, MA, USA) in basal M131 medium and were fixed for SEM preparation.

    Techniques:

    Thrombospondin 1 (TSP1)-induced defenestration was independent of TGF-β1 signalling. (A) SEM images of liver sinusoidal endothelial cells (LSEC)s pretreated with SB-431542 for 1 h before addition of TGF-β1 or TSP1 (a) Control; (b) SB-431542; (c) TSP1; (d) SB-431542+TSP1; (e) TGF-β1; (f) SB-431542+TGF-β1. All scale bars are 1 μm. (B) Porosity/μm 2 and (C) Fenestrae number/μm 2 after treatment with SB-431542, TSP1 and TGF-β1 (* represents P < 0.05 for one-way anova applied to the control, TSP1, and SB-431542+TSP1 treatments).

    Journal: Liver International

    Article Title: The CD47-binding peptide of thrombospondin-1 induces defenestration of liver sinusoidal endothelial cells

    doi: 10.1111/liv.12231

    Figure Lengend Snippet: Thrombospondin 1 (TSP1)-induced defenestration was independent of TGF-β1 signalling. (A) SEM images of liver sinusoidal endothelial cells (LSEC)s pretreated with SB-431542 for 1 h before addition of TGF-β1 or TSP1 (a) Control; (b) SB-431542; (c) TSP1; (d) SB-431542+TSP1; (e) TGF-β1; (f) SB-431542+TGF-β1. All scale bars are 1 μm. (B) Porosity/μm 2 and (C) Fenestrae number/μm 2 after treatment with SB-431542, TSP1 and TGF-β1 (* represents P < 0.05 for one-way anova applied to the control, TSP1, and SB-431542+TSP1 treatments).

    Article Snippet: To show the long-term, general effect of TSP1 on LSECs, cells in were treated for 12 h with different doses (0 ng/ml, 10 ng/ml and 100 ng/ml) of purified human platelet TSP1 (Millipore, Billerica, MA, USA) in basal M131 medium and were fixed for SEM preparation.

    Techniques: Control

    Defenestration was induced by a peptide from the Thrombospondin 1 (TSP)1 C-terminal domain. (A) Domains of TSP1 and the origins of the recombinant peptides from the C-terminal binding domain (CBD). Amino acid residues differing from the native TSP1 residues are underlined. (B) Porosity/μm 2 and (C) Fenestrae number/μm 2 of liver sinusoidal endothelial cells (LSEC) after treatment with CBD peptides. (D) Distribution of LSEC fenestrae diameter after peptide treatment. (* represents P < 0.05 for one-way anova applied to Control, p4N1 and p4G1 treatments).

    Journal: Liver International

    Article Title: The CD47-binding peptide of thrombospondin-1 induces defenestration of liver sinusoidal endothelial cells

    doi: 10.1111/liv.12231

    Figure Lengend Snippet: Defenestration was induced by a peptide from the Thrombospondin 1 (TSP)1 C-terminal domain. (A) Domains of TSP1 and the origins of the recombinant peptides from the C-terminal binding domain (CBD). Amino acid residues differing from the native TSP1 residues are underlined. (B) Porosity/μm 2 and (C) Fenestrae number/μm 2 of liver sinusoidal endothelial cells (LSEC) after treatment with CBD peptides. (D) Distribution of LSEC fenestrae diameter after peptide treatment. (* represents P < 0.05 for one-way anova applied to Control, p4N1 and p4G1 treatments).

    Article Snippet: To show the long-term, general effect of TSP1 on LSECs, cells in were treated for 12 h with different doses (0 ng/ml, 10 ng/ml and 100 ng/ml) of purified human platelet TSP1 (Millipore, Billerica, MA, USA) in basal M131 medium and were fixed for SEM preparation.

    Techniques: Recombinant, Binding Assay, Control